| Year | Movie | Role | Director |
|---|---|---|---|
| 2021 | Those Who Wish Me Dead | Hannah Faber | Taylor Sheridan |
| 2021 | Eternals | Thena | Chloé Zhao |
| 2020 | Come Away | Rose Littleton | Brenda Chapman |
| 2020 | The One and Only Ivan | Stella (voice) | Thea Sharrock |
| 2019 | Maleficent: Mistress of Evil | Maleficent | Joachim Rønning |
| 2016 | Kung Fu Panda 3 | Master Tigress (voice) | Jennifer Yuh Nelson |
| 2015 | By the Sea | Vanessa | Angelina Jolie Pitt |
| 2014 | Maleficent | Maleficent | Robert Stromberg |
| 2011 | Kung Fu Panda 2 | Master Tigress (voice) | Jennifer Yuh Nelson |
| 2011 | Kung Fu Panda: Secrets of the Masters | Master Tigress (voice) | Tony Leondis |
| 2010 | Salt | Evelyn Salt | Phillip Noyce |
| 2010 | The Tourist | Elise Clifton-Ward | Florian Henckel von Donnersmarck |
| 2008 | Kung Fu Panda | Master Tigress (voice) | John Stevenson Mark Osborne |
| 2008 | Wanted | Fox | Timur Bekmambetov |
| 2008 | Changeling | Christine Collins | Clint Eastwood |
| 2007 | A Mighty Heart | Mariane Pearl | Michael Winterbottom |
| 2007 | Beowulf | Grendel’s mother | Robert Zemeckis |
| 2006 | The Good Shepherd | Margaret “Clover” Russell Wilson | Robert De Niro |
| 2005 | Confessions of an Action Star | Herself (cameo) | Brad Martin |
| 2005 | Mr. & Mrs. Smith | Jane Smith | Doug Liman |
| 2004 | Taking Lives | Illeana Scott | D. J. Caruso |
| 2004 | Shark Tale | Lola (voice) | Vicky Jenson Bibo Bergeron Rob Letterman |
| 2004 | Sky Captain and the World of Tomorrow | Franky Cook | Kerry Conran |
| 2004 | The Fever | Revolutionary (cameo) | Carlo Gabriel Nero |
| 2004 | Alexander | Olympias | Oliver Stone |
| 2003 | Lara Croft: Tomb Raider – The Cradle of Life | Lara Croft | Jan de Bont |
| 2003 | >Beyond Borders | Sarah Jordan | Martin Campbell |
| 2002 | Life or Something Like It | Lanie Kerrigan | Stephen Herek |
| 2001 | Lara Croft: Tomb Raider | Lara Croft | Simon West |
| 2001 | Original Sin | Julia Russell | Michael Cristofer |
| 2000 | Gone in 60 Seconds | Sara “Sway” Wayland | Dominic Sena |
| 1999 | Pushing Tin | Mary Bell | Mike Newell |
| 1999 | The Bone Collector | Amelia Donaghy | Phillip Noyce |
| 1999 | Girl, Interrupted | Lisa Rowe | James Mangold |
| 1998 | Hell’s Kitchen | Gloria McNeary | Tony Cinciripini |
| 1998 | Playing by Heart | Joan | Willard Carroll |
| 1997 | Playing God | Claire | Andy Wilson |
| 1996 | Without Evidence | Jodie Swearingen | Gill Dennis |
| 1996 | Love Is All There Is | Gina Malacici | Joseph Bologna Renée Taylor |
| 1996 | Mojave Moon | Ellie Rigby | Kevin Dowling |
| 1996 | Foxfire | Legs Sadovsky | Annette Haywood-Carter |
| 1995 | Hackers | Acid Burn | Iain Softley |
| 1993 | Cyborg 2 | Casella “Cash” Reese | Michael Schroeder |
| 1982 | Lookin’ to Get Out | Tosh | Hal Ashby |
